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| Yellow-green fluorescence of Clostridium difficile under long-wave UV irradiation on a CCFA plate. Photo: James Gathany |
ATLANTA, Georgia -- The majority of pediatric Clostridium difficile infections,
which are bacterial infections that cause severe diarrhea and are
potentially life-threatening, occur among children in the general
community who recently took antibiotics prescribed in doctor’s offices
for other conditions, according to a new study by the Centers for
Disease Control and Prevention published this week in Pediatrics.
The study showed that 71 percent of the cases of C. difficile
infection identified among children aged 1 through 17 years were
community-associated—that is, not associated with an overnight stay in a
healthcare facility. By contrast, two-thirds of C. difficile infections in adults are associated with hospital stays.
Among the community-associated pediatric cases whose parents were
interviewed, 73 percent were prescribed antibiotics during the 12 weeks
prior to their illness, usually in an outpatient setting such as a
doctor’s office. Most of the children who received antibiotics were
being treated for ear, sinus, or upper respiratory infections. Previous
studies show that at least 50 percent of antibiotics prescribed in
doctor’s offices for children are for respiratory infections, most of
which do not require antibiotics.
“Improved antibiotic prescribing is critical to protect the health of our nation’s children,” said CDC Director Tom Frieden, M.D., M.P.H. “When antibiotics are prescribed incorrectly, our children are needlessly put at risk for health problems including C. difficile infection and dangerous antibiotic resistant infections.”
C. difficile, which causes at least 250,000 infections in
hospitalized patients and 14,000 deaths every year among children and
adults, remains at all-time high levels. According to preliminary CDC
data, an estimated 17,000 children aged 1 through 17 years get C. difficile infections every year. The Pediatrics study found that there was no difference in the incidence of C. difficile
infection among boys and girls, and that the highest numbers were seen
in white children and those between the ages of 12 and 23 months.
Taking antibiotics is the most important risk factor for developing C. difficile
infections for both adults and children. When a person takes
antibiotics, beneficial bacteria that protect against infection can be
altered or even eliminated for several weeks to months. During this
time, patients can get sick from C. difficile picked up from contaminated surfaces or spread from a health care provider’s hands.
